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AO can interact with metabolic Glu receptor 5 to promote long-term depression and inhibit long-term potentiation in the hippocampus, leading to downstream responses and kinases activation

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Eli Lilly (NYSE: LLY) saw its shares climb 5% this past week after announcing that its history-making oral obesity candidate, orforglipron aced the Phase III ATTAIN-2 trial (NCT05872620), which assessed the small molecule glucagon-like peptide-1 (GLP-1) receptor agonist in adults who were obese or overweight and had type 2 diabetes