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Acknowledgements This work was supported by the National Innovation of Science and Technology-2030 (Program of Brain Science and Brain-Inspired Intelligence Technology, Grant 2021ZD0204002)

The use of CoA in metabolic signaling relates to the roles of various acylated CoA molecules, such as acetyl-CoA, crotonyl-CoA, that serve to acylate lysine residues in the nuclear histone proteins, such as is the case for nuclear acetyl-CoA, succinyl-CoA, butyryl-CoA, and propionyl-CoA