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8.6 Renal Impairment Compared to healthy volunteers with normal renal function, patients with moderate and severe renal impairment as estimated by the Cockcroft-Gault equation had higher exposures to phentermine and topiramate

The figures below are from the FDA-approved Increlex labeling

Their findings revealed a 30% reduction in MACE compared to monotherapy

These observations allowed postulating that intracellular redox state of the thiol pool, which strongly depends on GSH level, can drive autophagic response at multiple levels (Filomeni et al., 2010)