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SB-01 is a synthetic 7-amino-acid peptide in clinical trials that downregulates TGF-beta-1, a growth factor highly expressed in degenerated discs

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Similarly, in the enteric nervous system, the loss of neurons is replenished by neurogenesis precursor cells that behave like stem cells and are prominent in the submucosal zone and in the muscular layers ( in vitro, that a selective estrogen receptor (ER) agonist, LY3201, stimulated glial-to-neuron cell differentiation