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It is engineered to penetrate the nuclei of chondrocytes and fibroblasts, interacting directly with chromatin to reactivate the gene expression programs associated with tissue repair
Responses are typically dose- and time-dependent, and treatment may need to be repeated cyclically or maintained over time for sustained benefits
Bacteriostatic water containing 0.9% benzyl alcohol is generally preferred over plain sterile water because it suppresses microbial growth during multi-dose use
Dihydroergotamine mesylate nasal spray is contraindicated in patients who have previously shown hypersensitivity to ergot alkaloids
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