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At the mechanistic level, dysregulation of SCFAs contributes to the pathogenesis of PCOS through multiple pathways: first, decreased SCFAs (including butyrate) reduce the expression of intestinal tight junction proteins, increasing gut permeability and allowing LPS translocation into circulation, which triggers chronic low-grade inflammation

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Abstract Neurodegenerative diseases are characterized by progressive neuronal dysfunction, often accompanied by chronic inflammatory states and redox imbalance within the central nervous system (CNS)

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