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However, it is rendered ineffective when evaluating possible toxicity due to multiple ingestions over time, when time of ingestion is unknown, or when altered metabolism occurs

Additionally, small, frequent meals are recommended, along with avoiding alcohol.[ref] Benefits for CVD : In a huge cardiovascular disease study, GLP-1 RAs were shown to be associated with a lower risk of heart attacks and strokes.[ref] Nutritional considerations on a GLP-1 RA: Nutrition researchers from Harvard recommend the following while on a GLP-1:[ref] Protein: Aim for 1 1.5g/kg of body weight in order to maintain muscle mass while on a GLP-1 RA