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By contrast, a 17-g increase in fat intake and a 50-g increase in carbohydrate intake was associated with a higher likelihood of wrinkles and skin atrophy.4 Discussion Demand for skin antiaging therapies is high and expected to increase.15 The use of oral supplements and systemic drugs to fight skin aging is an attractive option, as it would eliminate or reduce the need for topical treatments or invasive or minimally invasive procedures, which can be costly and are not without adverse effects

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However, it is currently unclear and to what extent the differences observed in CVOT reflect the heterogeneous pharmacological properties of each drug in the GLP-1RA category

160 Amato et al