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10.1016/S0140-6736(22)01272-7 32 FengF.LiX.WangW.DouM.LiS.JinX.et al (2024a)

Thyroid hormones lead to heat generation in humans

Clinical studies consistently report elevated circulating and central levels of pro-inflammatory cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-), in patients with major depressive disorder, with cytokine concentrations often correlating with symptom severity, illness chronicity, and treatment resistance (30, 32)

The converging evidence across neurotransmitter systems highlights that multiple mechanisms potentially affect LLD