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Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]

Since it is abundant in hypothalamus, it can affect the neuronal activity and thus hypothalamo-pituitary gonadal (HPG) axis to exert its impact on female reproduction [16]

Quando administrada por injeo subcutnea, a semaglutida estimula a secreo de insulina, inibe o glucagon, retarda o esvaziamento gstrico e promove a saciedade, resultando na reduo dos nveis de glicose no sangue e na perda de peso em pacientes com DM2 e obesidade (BAGGIO