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After menopause, estrogen levels drop sharply, leading to: Increased osteoclast activity Accelerated bone resorption Rising urinary DPD levels This makes DPD testing particularly valuable for postmenopausal women , helping identify those at highest risk for rapid bone loss

The dROMs value, an index of oxidative metabolites in blood, was higher after DSS administration than that in normal condition regardless of the Si-based agent administration, and it was higher on the 5th day than on the 3rd day (Fig