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Retatrutide's fatty-acid acylation chemistry (explained below) extends its residence in the bloodstream, making once-weekly subcutaneous injection viable

Funding This research was supported by the China Postdoctoral Science Foundation (2021M701420), Guangdong Basic and Applied Basic Research Foundation (2022A1515110021), Guangzhou Science and Technology Projects Foundation (202201020002), Scientific Research Project of Guangdong TCM Bureau (20221105), Guangdong Medical Research Foundation (A2022214)

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