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Empagliflozin Reduced Mortality and Hospitalization for Heart Failure Across the Spectrum of Cardiovascular Risk in the EMPA-REG OUTCOME Trial

The percentage of recycled receptor was calculated by subtracting residual median fluorescence following the recycling protocol from that measured at t = 15 min, and normalizing to the percentage of internalized receptor at the same t = 15 min time-point

Additionally, the trial reported renal-related adverse events, including serious adverse events, at a higher rate compared to the placebo group

Structured programmes incorporating dietary modification, physical activity, and behavioural support can produce meaningful improvements