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Many of these processes, however, are impractical for industrial-scale production because they involve several time-consuming phases

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In these situations, there is "reasonable probability that the use of or exposure to a product will cause serious adverse health consequences or death." Class II recalls are for drugs that may cause temporary or medically reversible adverse health consequences or where use of the product is unlikely to result in serious adverse health consequences

[12] Because Niacin needs can be met from tryptophan, The RDA is expressed in niacin equivalents (NEs)