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In a trial enrolling overweight diabetics, hypoglycemia occurred in 4.2% of tirzepatide-treated patients and 1.3% of placebo-treated patients, with tirzepatide-treated patients taking insulin secretagogues having the greatest risk (10.3%)

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Mice were single-housed and transferred to Promethion Metabolic chambers (Sable Systems International) at the Vanderbilt Mouse Metabolic Phenotyping Center (VMMPC) and acclimated for 3 days (for mice at RT) to 6 days (for mice at TN)

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