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This imbalance increases oxidative stress, places additional demand on antioxidant systems, and may contribute to cellular and tissue injury rather than toxin clearance

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Some guidelines recommend holding GLP-1 receptor agonists before procedures requiring sedation or general anesthesia to reduce the risk of aspiration, though specific recommendations may vary based on the procedure type and individual patient factors

Sardoiwala MN, Srivastava AK, Kaundal B, Karmakar S, Choudhury SR (2020) Recuperative effect of metformin loaded polydopamine nanoformulation promoting EZH2 mediated proteasomal degradation of phospho--synuclein in Parkinson's disease model