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A loss-of-function study showed that Nrf2 knockout (Nrf2 (/) ) mice had more severe neurological deficits, brain edema, and neuronal cell apoptosis compared with Nrf2 (+/+) mice and were more susceptible to diseases related to oxidative stress, with higher expression of genes in the ER stress and ER stress-induced apoptotic pathways [60]

Hi there, I also have a low homocysteine level 4,51mol/l

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These two mechanisms may work independently of each other, since the decline of circulating GH by IGF-1 infusion occurred despite rapid insulin suppression [22]