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While the medication is mainly used to manage type 2 diabetes and aid weight loss, it can also improve mental health through blood sugar stabilization, weight loss, and potential effects on neurotransmitter control and brain function

I think the very important thing for this trial is, it is a different kind of patient population

A "thrifty" genotype was defined as "being efficient in the intake and/or utilization of food." Thus, during famines, individuals with a "thrifty" genotype would have a survival advantage because they relied on larger, previously stored energy to maintain homeostasis, whereas those without "thrifty" genotypes would be at a disadvantage and less likely to survive (4)

As weight decreases and fitness improves, graduated activity becomes safer and often more sustainable