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To address this limitation, multimodal biomarkers have been developed, including fluid markers such as plasma GFAP and chitinase-3-like protein 1 (YKL-40) that differentially associate with amyloid versus tau pathology, positron emission tomography (PET) tracers targeting astrocytic MAO-B that provide complementary in vivo readouts and proteomic analyses identifying novel candidates such as VCAM1 and BST2 141,142,143,144