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[Abstract] 3nitropropionic acid (3NP, 1mM)

(C) Using murine models and in vitro studies with bacteria derived from humans, several bacterial genera were identified as producers of 3-oxoLCA, including Gordonibacter pamelaeae P7-E3, Eggerthella lenta P7-G7, Raoultibacter massiliensis P7- A2, Collinsella intestinalis P8-C1, Adlercreutzia equolifaciens P11-C8 , and Clostridium citroniae P2-B6

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The activation of GLP-1R triggers a complex intracellular signaling cascade, which at the end activates protein kinase A (PKA) pathway via production of cyclic adenosine monophosphate (cAMP) (12)