Key Nutrients Depleted by Corticosteroids Corticosteroids are associated with depletion of multiple nutrients essential for tissue repair, immune defense, and metabolic stability, including: Calcium, vitamin D, magnesium, potassium, zinc, selenium, vitamin C, and protein (1) Mechanisms of Steroid-Induced Nutrient Depletion Calcium & vitamin D: Reduced intestinal absorption and increased urinary loss osteopenia and fracture risk Zinc, selenium & vitamin C: Impaired immune function, delayed wound healing, increased infection risk Protein: Accelerated protein breakdown muscle wasting and connective tissue weakness Magnesium & potassium: Electrolyte imbalance fatigue, weakness, and cardiac rhythm disturbances Why Steroid-Induced Nutrient Depletion Impairs Healing By chronically elevating cortisol signaling, corticosteroids shift the body into a catabolic, stress-dominant state
Nat Chem Biol 12:497503 Chen X, Li J, Kang R, Klionsky DJ, Tang D Ferroptosis: machinery and regulation
FDA Regulatory Status Clarification Injectable glutathione as described in this publication is compounded by FDA-registered pharmacies but is not an FDA-approved drug product
Yuan C, Parekh H, Allegra C, George TJ, Starr JS (2019) 5-FU induced cardiotoxicity, case series and review of the literature
