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Insulin secretion and GLP-1R protein expression in pancreatic islets

Cell 24 , 23982405 (2013)

In Summary it led to : A1c Reduction up to 2% Weight loss reaching 29% Reduced Liver fat Drop blood pressure by 14 points decreased inflammatory markers reduced osteoarthritis flare ups Retatrutide shows significant weight loss in obesity and knee osteoarthritis trial In the Phase 3 TRIUMPH-4 trial (68 weeks), retatrutide demonstrated unprecedented weight loss in adults with obesity and knee osteoarthritis, with participants on the highest dose (12 mg) achieving an average weight loss of 28.7% (approximately 71 lbs)