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Lipotoxicity refers to lipid metabolism disorders leading to an increase in FFA, excessive FFA makes pancreatic islet -cells dysfunctional, inducing them to produce a large amount of NO, causing a series of cytotoxic injuries

Carefully designed trials assessing semaglutide-resmetirom combinations, integrated histologic, NIT, and molecular endpoints, could help define a new paradigm for multi-targeted metabolic and hepatic risk reduction in MASLD