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Semaglutide currently has stronger evidence for heart health, making it the preferred option for patients with existing cardiovascular disease

However, without clear evidence of efficacy, they might struggle to compete with established forms of GLP-1 therapy

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As a consequence, IEC metabolism shifts to anaerobic pathways leading to elevated mucosal oxygen concentrations, thereby facilitating colonisation by facultative anaerobes which are responsible for gut-associated inflammation (Byndloss et al