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(See the Side effects in children section above to learn more about this side effect in children.) In rare instances, stimulants such as Vyvanse can cause or worsen serious mental health conditions

(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux

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Months 4 through 12 represent the sustained weight loss phase where most people achieve their maximum results