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On the other hand, activation of the bile acid nuclear receptor farnesoid X receptor (FXR) changes the structure of the gut microbiota, thus affecting the metabolism of bile acid and inducing the activation of intestinal grain filling rate 5 to increase the secretion of glucagon-like peptide-1 in intestinal endocrine L-cells to control glucose homoeostasis and improve liver insulin sensitivity and liver metabolism

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In preclinical studies, CB-839 has demonstrated cytotoxic effects on various types of tumors, including triple-negative breast cancer