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Moreover, SELENOM deletion inhibits the expression of FAO-related genes ( Ppara , Cpt1 , Cdh15 , Acox1 and Acadm ), and increases the expression of lipogenic genes ( Gpam , Plin1 , Scd1 , Lipe , Fasn , Acly, and Pparg ) ( NF-kB and Nrf 2 signaling), the Wnt signaling pathway, protein synthesis pathway ( 2 O 2 produced by thyroid cells during thyroid hormone synthesis, which can lead to thyroid cell necrosis and increased macrophage invasion in severe nutritional Se deficiency ( 6 Antioxidant mechanism of different Se forms in fish In the intensive aquaculture system, cultured fish mainly obtain the selenium from the feed