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Based on FDA guidance and current clinical recommendations, the following groups should avoid or exercise extreme caution with GLP-1 receptor agonist peptides: Pregnant or planning pregnancy The FDA recommends discontinuing semaglutide at least two months before a planned pregnancy

Temporal impact of treatment duration on tumor risk The duration of treatment with GLP-1RAs is a critical factor influencing clinical outcomes

Eur Rev Med Pharmacol Sci 17(Suppl 1):2833 Sharma AP, Sharma G, Kumar R (2022) Systematic review and meta-analysis on effect of carnitine, coenzyme q10 and selenium on pregnancy and semen parameters in couples with idiopathic male infertility

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