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Due to the decreasing of PLC levels during cancer progression, it has been postulated that PLC downregulation is important for this process

[11] The researchers also reported the presence of p63 protein in the epidermal stem cells

If one assumes that the primary function of ferrous iron involves catalyzing the Fenton reaction to reductively cleave hydrogen peroxides and lipid hydroperoxides, initiating and propagating LPO, then the iron data clearly contradicts and is incompatible with the previous hypothesis that peroxynitrite is a critical mediator of APAP toxicity

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