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The use of compounded drugs in patients using GLP-1s without medical supervision pose significant risk and can result in significant consequences, said Marina Basina, MD, a clinical professor in endocrinology, gerontology and metabolism

The Wegovy pill (oral semaglutide, approved December 2025) has to be taken on an empty stomach with a 30-minute wait before eating, every morning, no exceptions

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Some populations, such as adolescents with migraine who suffer from comorbid obesity, may be of interest for further study, as GLP-1 agonists could potentially relieve pain while also addressing obesity [59]