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At low levels, exercise-induced ROS play a critical role in skeletal muscle adaptation [95] by up-regulating various cytokines and protein kinases such as tumor necrosis factor alpha (TNF-) [96] and mitogen-activated protein kinases (MAPK) [97] that work to signal increases in mitochondrial density and number, endogenous antioxidants, and assist in muscle protein synthesis [98, 99]

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This helps to darken or color certain areas, making it easier for patients to see while also improving the appearance of their eyes

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