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Con las cantidades presentes de Lisina en los suplementos no se han descrito problemas reproducibles en el hombre, aunque ocasionalmente se han descrito clicos y diarrea transitoria con dosis muy altas (15-40 gramos al da)

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Clinical evidence includes stroke trials where 5 mg/day riboflavin, often in combination with other B vitamins, improved erythrocyte glutathione reductase activity and reduced the proportion of biochemically riboflavin-deficient patients, although clinical outcomes remain understudied (57)

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