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Methylmalonic acid, if not properly handled by B 12 , remains in the myelin sheath, causing fragility

[77] This suppression may create a rationale for melatonin supplementation in patients taking beta-blockers who experience sleep disturbances, though the optimal dosing and timing strategies in this population require further research

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Those with a history of liver or kidney disease should use it under medical supervision as it is metabolized and eliminated by these organs