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doi: 10.1016/j.diabres.2021.108998 39 KaaksRLukanovaA

In previous Phase 2 clinical trials, participants reported an average weight loss of about 22.8% (with an 8mg dose) and 24.2% (with 12mg) after retatrutide for 11 months

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A large set of questionnaires may be used for assessing specifically fatigue, anxiety, depression, quality of sleep, autonomic dysfunction (see e.g (127, 305)