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In addition to its direct effects on the cardiovascular system, HO-1 may also indirectly affect the occurrence and development of cardiovascular diseases in diabetes by regulating other biological processes

The EGF receptor is inhibited in keratinocytes at the non-healing edge (Pastar et al., 2010)

Serum limitation-induced senescent fibroblasts model and effect of FOXO4-DRI Passage 3 fibroblasts derived from keloids and normal skins were cultured in a Dulbeccos Modified Eagles medium (DMEM, Hyclone, Logan, Utah, USA) containing 10% fetal bovine serum (FBS, Gibco, Grand Island, NY, USA) to 90% confluence, and then cultured in a DMEM containing 2% FBS for 3 days to construct a serum limitation-induced senescent fibroblast model

doi: 10.1093/carcin/16.9.2099