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Together, as MTHFR is an important enzyme for folate metabolism which plays critical role in epigenetic as DNA methylation, accumulated evidence showed that global DNA methylation can be associated with MTHFR polymorphism genotypes in both healthy populations and individuals with various diseases

Methods Enzyme identification and subfamily classification We searched for gene sequences encoding candidate members of the CAT, PRX, and GPX families in high quality genomes of 19 metazoan species representing 10 phyla (Supplementary file 1, Table S1)

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Chemistry 27(7):22892293