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Clinical trials show average weight loss of 15-22% over 68 weeks on semaglutide alone, with some patients reaching 25%+ loss

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Average Weight Loss on Semaglutide In the main clinical trial that supported semaglutide's approval for weight management (the STEP 1 trial), adults who took the 2.4 mg weekly dose lost, on average, about 15% of their body weight over 68 weeks, compared with a much smaller amount in the placebo group

A recent trial published in JAMA Network Open (Shiwach et al., 2025), sponsored by Indivior Inc., evaluated BUP-XR (Sublocade) in conjunction with Suboxone during induction