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While the origins of the observed differences between mice and humans with respect to the l-carnitineBBTMATMAO pathway are not clear, the fact that the second reaction in the conversion of l-carnitine into TMA (i.e., BBTMA) showed marked induction with dietary exposure in subjects likely plays a major role in the observed differences

doi: 10.1515/jpem-2014-0283 152 AllenHFMazzoniCHeptullaRAMurrayMAMillerNKoenigsLet al