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Therefore, melatonin regulates several physiological functions, playing essential roles in regulating body temperature, metabolic control, glycemic and lipid control, cardiovascular and immune system control, reproduction and pregnancysuch as the secretion of gonadotropin-releasing hormone, gonadotropins, follicle-stimulating hormone, and luteinizing hormone neural development, and protection [2,3,4]

Some peptides may also be available in oral or nasal spray form depending on the formulation and purpose

Finally, it should be noted that BUDCA is orally administered whereas some other agents being developed require regular subcutaneous injection or even intravenous infusion 30,37

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