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Yes, without proper nutrition and resistance training, part of the weight loss can come from muscle mass

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Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury

Exenatide treatment and co-infusion of d3-leucine 5 h after starting continuous infusion of lipid/carbohydrate formula in healthy fasted humans via nasoduodenal tube 2 h after starting a pancreatic clamp does not significantly affect plasma TG, FFA, or TRL-TG compared to placebo (Xiao et al., 2012)