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Slowed gastric emptying from GLP-1 therapy combined with a smaller post-bypass stomach may increase the risk of nausea or vomiting if doses are escalated too quickly

Cunningham, D

Critical evaluation of pharmacokinetic and biodistribution data reveals that these issues remain major translational bottlenecks that must be addressed through rational design and precise redox profiling

An optimized LBF composed of 85% Labrafac MC60, 10% Kolliphor RH40, and 5% propylene glycol was developed, with a final particle size of 106 nm, and it was loaded with 6 mg/g solubilized EXE (HIP form) and 20 mg/g of sodium caprate (complementary permeation enhancer)