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Casanueva FF, Moreno B, Rodriguez-Azeredo R, Massien C, Conthe P, Formiguera X, et al

Moreover IR in PCOS was shown to destroy the effect of gonadotropins, enhance the sensitivity of follicular membrane cells to the luteinizing hormone, and increase the expression of P450c17 and 3-hydroxysteroid dehydrogenase type 2, leading to increased production of androgen (152)

Why oral contraceptives might not be ideal on GLP-1s: GLP-1 medications slow gastric emptying (how fast food leaves your stomach)

However, this inhibitory effect is significantly weakened in patients with T2DM, indicating that its potential application in diabetes treatment requires further investigation