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While the above evidence indicates that the mitochondrial apoptotic pathway promotes cell death, recent provocative evidence has shown that the intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in Caenorhabditis elegans by triggering a unique pattern of gene expression that modulates stress sensitivity and promotes survival (Yee et al., 2014)

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Notably, in macrophages, this pathway is triggered during renal fibrogenesis by double-stranded DNA emanating from injured renal tubular epithelial cells (RTECs), thereby instigating a robust inflammatory cascade (Fumika et al., 2023)

Unlike patents of addition (under Section 54), which expire with the core patent, these independent secondary patents have their own 20-year terms