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whereas, their role in T2D (Type 2 diabetes), historically considered to not be an immune-mediated condition, has not been clarified yet ( FOXP3 (Forkhead box P3) is implicated in the role and the function of Tregs

Notably, TMA-producing bacteria remained present after treatmentmeaning the mechanism was inhibitory (blocking the TMA lyase enzyme) rather than bactericidal, which avoids the collateral dysbiosis associated with antibiotic approaches

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An age-related trend in ETD was noted, with statistically insignificant ETDs amongst those aged 18-30 and 30-40, but significant differences amongst age groups above 40 years old