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In the following sections, we will delineate the expression profiles and functional mechanisms of the Vitamin DVDR signaling axis distinct cutaneous cell types, thereby revealing its diverse biological roles in maintaining skin homeostasis and responding to aging-related stressors

Although efforts have been made to develop glycolysis-targeting agents, inhibitors of HIFs, and immune checkpoint inhibitors for treating GBM, all therapeutic approaches present elevated toxicity without improvement in the outcomes of patients with GBM [13,14,15,16,17]