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Key takeaways GLP-1 medications do not inherently cause muscle wasting. Most weight lost on semaglutide or tirzepatide is fat , not muscle. Some lean-mass loss during weight loss reflects adaptive remodeling , not pathology. Adequate protein intake and resistance training significantly reduce muscle loss during GLP-1 therapy. Do GLP-1 Medications Cause Muscle Wasting

Semaglutide: Selective GLP-1 receptor agonist with C18 fatty diacid acylation enabling albumin binding and ~7-day half-life

O interessante que, na dose de 4 mg, a taxa de descontinuao por efeitos adversos foi menor do que no grupo placebo, o que sugere boa tolerabilidade nessa faixa posolgica