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Laboratory evaluation Clinicopathologic changes in the course of liver diseases are as variable and non-specific as the physical findings, nevertheless liver disease is often first diagnosed during routine blood tests

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The other listed methods use different markers for DNA damage including the 3-hydroxyl terminal deoxynucleotidyl transferase enzyme found on the free ends of DNA breaks, the production of chromatin halo following DNA denaturation, and the measurement of protein depletion using single-cell electrophoresis [50]