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Notably, melatonin also diminished the activity of PKA in a rat model [121], a known trigger for tau hyperphosphorylation by GSK3 [122, 123]

However, their dysregulation can exacerbate inflammation and tissue damage in ARDS ( Given the central role of oxidative stress and lipid peroxidation in ARDS, targeting ferroptosis represents a promising therapeutic strategy ( 2 Ferroptosis in infection and ARDS development Cell death pathways play critical roles in immune homeostasis, infection defense, and inflammation resolution