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doi:10.1158/1940-6207.CAPR-08-0167

Among the most well-characterized pathways, IL-6 secreted by CAFs and tumor-associated macrophages activates STAT3 signaling in CSCs, increasing the expression of stemness-associated transcription factors such as SOX2, OCT4, and NANOG

While a substantial amount of preclinical data has been published, human evidence for efficacy and safety remains limited, which is why BPC-157 is currently not approved for human consumption

The presentation of chronic hand dermatitis with fissuring requires patch testing to distinguish from atopic eczema