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J Drug Deliv Sci Technol 72:103362

This reaction requires -ketoglutarate, oxygen, and ascorbate (vitamin C) as cofactors and takes place in the mitochondria

[16] Calcium is, therefore, a cell signaling ion, and not usually considered a cofactor of the enzymes it regulates

Loss of mtGSH disrupts m, promotes MOMP, and activates intrinsic apoptotic signaling, whereas restoration of mtGSH via GSH ester supplementation suppresses apoptosis 38,40